With full treatment, you can see lasting results for up to 18 months in nasolabial folds with Restylane®;10 up to 12 months in the cheeks, up to 6 months in the back of the hands, and up to 6 months in facial wrinkles and folds, such as nasolabial folds, with Restylane® Lyft;3 6 months for lips and perioral rhytids with Restylane® Silk;11 and up to 12 months in the facial wrinkles and folds (such as nasolabial folds and marionette lines) with Restylane® Refyne and Restylane® Defyne.12,13
Restylane® Silk: In clinical studies, the results of Restylane® Silk lasted approximately 6 months following treatment. In a U.S. clinical trial involving 221 mostly female subjects, 98% of subjects reported a visible improvement in lip fullness in upper and lower lip (combined) 14 days after injection, and 77% still had lip improvement at 6 months following injection.11
Restylane® Lyft: In a clinical trial involving 150 subjects, blinded evaluators observed that 90% of subjects treated with Restylane® Lyft showed an improvement in fullness in the right and left midface areas (combined) at 2 months, and 54% of subjects showed an improvement at 12 months. Additionally, 95% of subjects reported that they were satisfied with the appearance of their midface at 2 months, and 73% of subjects were satisfied at 12 months.3 In a clinical trial involving 89 treated subjects, blinded evaluators observed that 86% of subjects* treated with Restylane® Lyft showed an improvement in volume of the back of the hands at 3 months, and 76% of subjects* showed an improvement at 6 months. Improvement was defined as subjects with a Merz Hand Grading Scale (MHGS) score of ≥1 grade from baseline by the blinded evaluator’s live assessment.3
*n=85 subjects treated.
Restylane®: In a clinical study treating the lines from the nose to the corners of the mouth (laugh lines), blinded evaluators reported that 95% of subjects improved for up to 18 months when they received an initial Restylane® treatment, plus a follow-up treatment approximately 4.5 or 9 months later. Using this Restylane® regimen of treatments, blinded evaluators reported similar subject improvement, on average, at 18 months compared to their Week 2 Wrinkle Severity Rating Scale (WSRS) score.10
Restylane® Refyne & Restylane® Defyne: In a clinical study of subjects treated for laugh lines with Restylane® Refyne and Restylane® Defyne, investigators reported improvement in the appearance of wrinkles for up to 12 months in the majority of patients. Using the Wrinkle Severity Rating Scale (WSRS), a validated 5-point measure of the size and depth of the wrinkles, with grade 1 defined as absence of wrinkles and grade 5 as extremely deep and long wrinkles, investigators reported that 79% of Restylane® Refyne subjects and 77% of Restylane® Defyne subjects had at least a 1-grade improvement on the WSRS after 6 weeks. Subjects also performed self-assessments (SSA) of wrinkle severity, with most reporting at least a 1-grade improvement in SSA scores with Restylane® Refyne and with Restylane® Defyne after 6 weeks.12,14,15
*The duration of effectiveness of Restylane® for the correction of nasolabial folds (NLFs) was evaluated in a randomized, evaluator-blinded multicenter study. Restylane® was shown to have an overall duration of effectiveness of 18 months from baseline following retreatment at 4.5 or 9 months.